Publications
Spotlighting our team’s publications. Click the links for details.
Dr. Magdalena Götz
Direct Neuronal Reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle
Highlights
- NDUFS4-mutant patient astrocytes are impaired in reprogramming into neurons
- Unfolded protein response inhibition improves neuronal reprogramming
- Patient iNs are affected in neuronal subtype specification
- Transient unfolded protein inhibition leads to more functional iNs
Dr. Pierre Mattar
The ChAHP chromatin remodelling comple regulates neurodevelopmental disorder risk genes to scale the production of neocortical layers
Highlights
- Adnp and Chd4 cKOs exhibit similar deficits in cortical growth
- Adnp sustains the proliferation of apical progenitors to scale the production of upper-layer neurons
- Adnp recruits Chd4 to genes involved in corticogenesis
- Adnp is a master regulator of risk genes associated with neurodevelopmental disorders
Resources
Resource 1
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches
Resource 2
Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application
Resource 3
Focused ultrasound gene delivery for the treatment of neurological disorders