iNeuron

Photo by Lauren Belfiore

Neuronal Reprogramming

A Canadian-led, international, interdisciplinary research project focused on the development of novel gene therapies to combat incurable neurological disorders. This innovative research project is supported by a $24 million New Frontiers in Research Fund-Transformation Program Grant.

Read more about the NFRF Transformation Program

Research Pillars

Gene Cargo

Optimize neuronal reprogramming gene cargo to engineer clinically relevant neuronal types.

Gene Delivery

Develop astrocyte-specific delivery system(s).

Translation

Assess outcome measures in animal models.

Cross-cutting Platform

Lived experience panel and law, governance and bioethics cross-cutting platform.

“At the heart of our mission lies the possibility of using direct neuronal reprogramming as a therapeutic strategy to replace lost neurons by changing the identities of the brain cells that remain, offering hope for patients facing conditions deemed untreatable.”