Publications
Spotlighting our team’s publications. Click the links for details.
Dr. Antonio Del Sol
Detecting expressed genes in cell populations at the single-cell level with scGeneXpress
Highlights
- scGeneXpress: a new computational tool designed for identifying expressed genes in single-cell RNA sequencing data.
- scGeneXpress improves the detection of genes expressed at low levels, allowing for a more precise understanding of cellular functions.
- This tool is useful for research in complex tissues, where distinguishing gene expression among different cell types is essential.
- The tool's design is accessible, making it a practical option for researchers without extensive computational expertise.
- This computational tool is relevant for cell engineering, since it enables a more accurate identification of the identity transcription factors of cell populations, which will be used for cellular conversion.
Dr. Carol Schuurmans
Examining the NEUROG2 lineage and associated gene expression in human cortical organoids
Highlights
- NEUROG1 and NEUROG2 are most highly expressed in basal neural progenitor cells, NEUROG1-derived lineages predominate early and NEUROG2 lineages later.
- NEUROG2 is necessary and sufficient to directly transactivate known target genes (NEUROD1, EOMES, RND2)
- Neurog2 similarly induces Col3a1 & Ppp1r17 in murine P19 cells, consistent with a conservation of NEUROG2 function across mammalian species.
Dr. Hon Leong
Next Generation Aqueous Two-Phase System for Gentle, Effective, and Timely Extracellular Vesicle Isolation and Transcriptomic Analysis
Resources
Resource 1
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches
Resource 2
Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application
Resource 3
Focused ultrasound gene delivery for the treatment of neurological disorders
ABLE Resources
The Advisory Board of Lived Experience (ABLE) of Stroke, Epilepsy, and Dementia is a dedicated group of individuals with lived experience who are meaningfully and actively involved in the iNeuron research process, including in governance, priority setting, conducting research and knowledge mobilization. Thus far, ABLE members have taken on roles as co-authors of knowledge mobilization products, designed for plain language and research audiences. These tools have helped to bridge knowledge gaps and align language between researchers and lived experience experts, making research more impactful for those who need it the most.
Team iNeuron Infographic
A visual guide outlining each pillar’s role within iNeuron.
Team iNeuron Guidebook
A live document to support ABLE members and researchers, detailing team goals, pillar aims, PI expertise, and a glossary of scientific terms in plain language.
Team iNeuron Tip Sheet
A tip sheet resource for researchers to use when preparing presentations for non-scientific audiences that includes accessibility considerations for people with lived experience.